<p>Yes. HUGE issues.</p>
<p>I would recommend simply reformatting the hard drive (after backing up your files) and then performing a clean install of Ubuntu 10.04LTS. An upgrade is going to go 32-bit to 32-bit or 64-bit to 64-bit, but not 32-bit to 64-bit.</p>
<p>You can use dpkg to export a list of installed applications on the current system and then also use dpkg to install those applications on the new system. Normally I would suggest just backing up your entire /home directory with all of its' .hidden folders, files and settings, but again, since you are migrating from 32-bit to 64-bit, I think it's best to just start all new to mitigate as much risk as possible between the 32-to-64-bit migration process.</p>
<p>If you were just upgrading from 9.10 to 10.04LTS and staying on 32-bit, then I'd suggest just backing up the /home directory as mentioned above.</p>